Usually these symptoms start within 36 hours of stopping the drug, and last for a couple of weeks. Because these symptoms can last several weeks or longer, long-term replacement drugs given by a clinician may be given in order to help symptoms. For many, this is the stage most likely to lead to relapse as many patients find it almost impossible to cope. Some facilities begin therapy and other forms of treatment at this stage, depending on the patient’s condition and ability. In inpatient detox, patients reside at a facility where they will receive constant supervision. This is considered the safest way to detox from many drugs, especially alcohol, Benzodiazepines, Barbiturates, and Opioids.